Books

Landmarks in Intracellular Signalling

Edited by RD Burgoyne and OH Peterson

University of Liverpool, UK

General

The intracellular signalling pathways that control cell function have been and still are, one of the most intensively studied aspects of biology. In recent years the detailed characterization of the multiple cell signalling pathways by many laboratories has resulted in a bewildering increase in knowledge in this field. For this reason, students and others learning about this topic for the first time are increasingly overwhelmed by the mass of information in this complex field and frequently are unable to find time to read and digest the key original papers.

The idea behind Landmarks in Intracellular Signalling is to provide full reproductions of a set of key papers which have been chosen as landmark papers in the various aspects of intracellular signalling. The chosen papers have all resulted in significant advances in one or other aspect of intracellular signalling. Readers will now have easy, readily available access to the original literature from one source.

The papers are accompanied by commentaries that describe why the papers are significant, how the work came about and summarise the advances that have occurred up to the present time as a consequence of the original paper. The commentaries will also serve as mini-reviews of many aspects of cell regulation and can be read on their own.

Contents:

• Cyclic AMP
  
• Identification and characterisation of G-proteins
  
• Structure of the b-adrenergic receptor
  
• The patch clamp technique
  
• The nicotinic acetylcholine receptor channel
  
• The role of cyclic GMP in photoreceptors
  
• Voltage sensitive Ca2+ channels
  
• Ca2+ uptake into intracellular stores
  
• Inositol 1,4,5 triphosphate releases Ca2+ from inttracellular stores
  
• Cytosolic Ca2+ spiking
  
• Protein kinase C
  
• Calmodulin
  
• The site of action of Ca2+ in exocytosis in neurons and neuroendocrine cells
  
• Endothelium-derived relaxing factor is nitric oxide
  
• Src:tyrosine phosphorylation and Src-homology domains in signal transduction pathways
  
• Phosphatidylinositol 3-kinase in signal transduction and intracellular membrane traffic
  
• The Ras/MAP kinase pathway
  
• Growth factors receptors and oncogenes
  
• Control of transcriptional by nuclear receptors
• Control of transcription by nuclear receptors
  
• Cyclic AMP regulation of gene transcription
  
• Subject Index
  
  

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