Books

Peptides in Mammalian Protein Metabolism

Edited by G Grimble and C Backwell

Addictive Behaviour Centre, Roehampton and Rowett Research Institute, Aberdeen, UK

Portland Press Proceedings

Proceedings of The Significance of Circulating Peptides in Protein Metabolism workshop on recent research and methodology.

Two new ideas were thoroughly discussed: firstly, that peptide metabolism is of greater quantitative significance in the whole-body nitrogen economy than has been assumed; and secondly, that provision of dietary nitrogen in peptide form may bring nutritional benefits. While this has been discussed extensively in relation to clinical nutrition, it's significance in relation to ruminant nutrition is novel. The demonstration that extracellular peptide-bound amino acids are preferentially used for protein synthesis by the lactating mammary gland is an exciting concept which raises the possibility of specific manipulation of milk protein synthesis by amino acid targeting. This phenomenon may be applicable to other tissues.

Anyone who reads this book should get a complete picture of the significance of circulating peptides, their metabolism and the most up-to-date methods which can be used to investigate this.

Contents:

• Peptide absorption and its significance in ruminant protein metabolism
  KE Webb and JC Matthews
  
• Transmucosal passage of intact peptides ML Gardiner
  
• Rumen fermentation as a source of peptides N McCain and RJ Wallace
  
• Methodological approaches for the quantification of peptide appearance across the gastro-intestinal tract CJ Seal and DS Parker
  
• Clearance of circulating dipeptides in humans W Druml ey al.
  
• Circulating peptides and their role in milk protein synthesis FRC Backwell
  
• Milk production responses to post-ruminal supply of peptide in dairy cows
  J -J Choung and DG Chamberlain
  
• Intestinal and renal transport of peptides at the cellular and molecular level
  H Daniel and M Herget
  
• Intravenous dipeptide metabolism and the design of synthetic dipeptides for clinical nutrition P Stehle et al.
  
• Protein hydrolysates as vehicles for the application of di- and tripeptides in clinical nutrition G Grimble
  
• Peptides as prodrugs — the `smugglin' concept J Payne et al.
  
• Peptide prodrugs: design and therapeutic imlications K Welham et al.
• A novel method for the identification of peptides in complex mixtures by tandem mass spectrometry with atmospheric pressure chemical ionization
  C Beaumont et al.
  

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