Books

Landmarks in Gene Regulation

Edited by D Latchman

University College London, UK

General

Twenty years ago there was no known example in eukaryotes of a defined regulatory protein which bound to as specific DNA sequence in a target gene and regulated its expression. Since that time a bewildering array of such regulatory proteins or transcription factors have been defined and their roles in regulating the expression of specific genes analyzed. When faced with such a vast array of information on individual factors, it is all to easy to forget that the foundations of the study of such factors and indeed of eukaryote gene regulation in general have been laid by a relatively small number of seminal papers which establish key points in this area.

Landmarks in Gene Regulation aims to provide access to these important classic papers which have appeared over the last twenty years together with a commentary which assesses their importance and places them in context of what was known at the time and that has been established subsequently. This will allow both the student and the more experienced research worker to see how the field has developed over this time and how the key principles were elucidated.

Contents:

• Different tissues have different RNA populations but generally similar DNA
• Regulation at transcription
  
• Post-transcriptional regulation: alternative RNA splicing
  
• Post-transcriptional regulation: RNA stability and tranlatability
  
• Chromatin Structure
  
• Promoter Elements
  
• Long distance regulatory elements
  
• Purification and cloning of transcription factors
  DNA binding domains of transcription factors
  
• Dimerization domains in transcription factors
  
• Activation domains in transcription factors
  
• Regulation of transcription factor activity
  
• Functional role of transcription factors
  
• Conclusions and future perpectives
  
  

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