Books

Protein Targeting and Translocation

Edited by DA Phoenix

University of Central Lancashire, UK

Monographs

Lipid bilayers are flexible self-sealing boundaries that are used to allow sub-cellular compartmentalisation of regions with different functions and hence different protein compositions. Within a eukaryotic organism up to 95%w/w of the cells membranes are used in the formation of intracellular structures such as the nucleus, endoplasmic reticulum (ER), Golgi, mitochondria, chloroplasts and microbodies (peroxisomes/glyoxisomes).

To allow each membrane bound compartment to carry out its role there is considerable protein traffic between compartments and proteins must be able to pass across these semi-permeable barriers, and in the case of membrane proteins insert into the bilayer. Furthermore the cell must have a means of maintaining proteins at their final functional location against the bulk flow of protein, for example in the ER and Golgi. The mechanism by which large amphiphilic proteins are able to undergo sub-cellular targeting and then cross a hydrophobic bilayer has been one that has puzzled scientists for a number of years and a question that has been investigated by a wide range of techniques from biophysics to molecular biology.

This book provides an overview of protein targeting with experts reviewing current developments in their area. By providing coverage of all the major eukaryotic and prokaryotic systems plus background information on protein membrane interaction, readers should not only be provided with coverage of their main areas of interest but, will have the opportunity to compare and contrast targeting to different organelles.

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