Books

Biochemical Society Symposia Volume 64
Cellular Responses to Stress

Edited by CP Downes, CR Wolf and DP Lane

University of Dundee, UK

Biochemical Society Symposia

Cellular Responses to Stress provides state-of the art information on the wide spectrum of mechanisms which cells, from simple prokaryotes to man, use to respond to different forms of stress induced by chemicals, oxidants and DNA damaging agents.

These mechanisms are fundamental to human health because they are crucial to the sensitivity of micro-organisms to chemotherapeutic agents, and they determine the sensitivity of normal and tumour cells to environmental agents and anti-cancer drugs. Research on these pathways is providing a wealth of new targets from which novel therapeutic agents are likely to emerge.

This book brings together some of the world's top scientists who work in different but inter-related aspects of cellular responses. They bring together aspects of the subject that in the past have been regarded independently.

The spectrum of topics is covered so as to provide a broad overview of our current knowledge of the different forms of adaptive response systems. The relevant pathways are charted from the earliest responses to stimuli at the cell surface via cytosolic signalling cascades to longer term adaptive responses involving altered patterns of gene expression.

Contents:

• Signal transduction by the c-Jun N-terminal kinase RJ Davis
  
• Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress DG Hardie
  
• Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses JM Kyriakis
  
• Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts JBA Millar
  
• Protein kinase cascades in intracellular signalling by interleukin-1 and tumour necrosis factor, J Saklatvala et al.
  
• Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27|kDa (Hsp27) J Landry and J Huot
  DNA-dependent protein kinase and related proteins GCM Smith et al.
  
• Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors JJ Cotto and RI Morimoto
  
• Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response B Demple et al.
  
• Adaptive responses to environmental chemicals CR Wolf et al.
  
• Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress JD Hayes et al.
  
• Subject index
  
  

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