Books

Biochemical Society Symposia Volume 65
Cell Behaviour: Control and Mechanism of Motility

Edited by JM Lackie, GA Dunn, and GE Jones

Yamanouchi Research Institute, Oxford, UK and The Randall Institute, King's College, London, UK

Biochemical Society Symposia

This book describes the latest molecular and genetic advances in the study of one of the most fundamental and yet least understood processes of life: the movement of cells.

Cell locomotion lies at the basis of embryological development, wound healing and the spread of cancers. The recent advances in identifying the molecular components of cell motility can be found in many publications but this text uniquely provides a synthesis of the molecular and phenomenological aspects that will be required for an understanding of the controlling processes that underlie cell behaviour.

Contents:

Section 1: Introduction

Patterns of cellular activities based on protein sorting in cell motility, endocytosis and cytokinesis G Gerisch et al.

Section 2: Motile Responses

New depths in cell behaviour: reactions of cells to nanotopography A Curtis and C Wilkinson

Self-organization of tissue-equivalents: the nature and role of contact guidance RT Tranquillo

Extracellular regulation of cancer invasion: the E-cadherin/catenin and other pathways V Noë et al.

Section 3: Signal Transduction

Towards a structural model of an integrin MJ Humphries

Integrin-mediated cell adhesion: the cytoskeletal connection DR Critchley et al.

Wnt factors in axonal remodelling and synaptogenesis PC Salinas

Rho family proteins and cell migration AJ Ridley et al.

Rho-like GTPases: their role in cell adhesion and invasion F Michiels and JG Collard

Section 4: Cytoskeletal Dynamics

Microtubule involvement in regulating cell contractility and adhesion-dependent signalling: a possible mechanism for polarization of cell motility
M Elbaum et al.

Organization and polarity of actin filament networks in cells: implications for the mechanism of myosin-based cell motility LP Cramer

Network contraction model for cell translocation and retrograde flow
AB Verkhovsky et al.

Centrosomes, microtubules and cell migration M Schliwa et al.

Cell migration as a five-step cycle MP Sheetz et al.

Section 5: Dynamics of Motility

Cytoskeletal protein mutations and cell motility in Dictyostelium I Weber et al.

Cell crawling two decades after Abercrombie TP Stossel et al.

Using molecular genetics as a tool in understanding crawling cell locomotion in myoblasts M Peckham et al.

Forces in cell locomotion EL Elson et al.

Section 6: Prospects

A dozen questions about how tissue cells crawl AK Harris

Subject index

Sales enquiries Portland Customer Services Portland Press Ltd. Commerce Way Colchester CO2 8HP UK Tel: +44 (0)1206 796351 Fax: +44 (0)1206 799331 E-mail: sales@portland-services.com Map

Editorial enquiries Portland Press Ltd. Third floor Charles Darwin House 12 Roger Street London WC1N 2JU Tel: +44(0) 20 7685 2410 Fax: +44(0) 20 7685 2469 E-mail: editorial@portlandpress.com