Books

Biochemical Society Symposia Volume 66
Mitochondria and Cell Death

Available Online

Edited by G C Brown, D Nicholls and C Cooper

University of Cambridge, UK, University of Dundee, UK and University of Essex, UK

Biochemical Society Symposia

This book reviews the involvement of mitochondria in cell death and disease. This is a rapidly expanding field of major importance to both basic biology and medical science. Clear and comprehensive chapters from some of the key researchers in the field cover most aspects of the subject from the molecular to the in vivo level. The role of mitochondria in neurodegenerative, inflammatory and ischaemic diseases, as well as necrosis, apoptosis and ageing is reviewed. Each chapter is by a different set of authors describing one aspect of the field.

Contents:

• Mitochondrial control of apoptosis: an overview G Kroemer
  
• Nitric oxide, cytochrome c and mitochondria GC Brown and V Borutaite
  
• Ceramide induces cytochrome c release from isolated mitochondria C Richter and P Ghafourifar
  
• Bcl-2 and Ca2+-mediated mitochondrial dysfunction in neural cell death
  AN Murphy and G Fiskum
  
• Mitochondria, NO and neurodegeneration MF Beal
  
• Excitotoxicity and mitochondria DG Nicholls et al
  
• Apoptosis and necrosis: different execution of the same death P Nicotera et al.
• The mitochondrial permeability transition: the brain's point of view
  JM Dubinsky et al.
• Mitochondrial dysfunction in Parkinson's disease JT Greenamyre et al.
  
• Secondary abnormalities of mitochondrial DNA associated with neurodegeneration SJ Tabrizi and AHV Schapira
  
• Mutations of the mitochondrial genome: clinical overview and possible pathophysiology of cell damage SM Rothman
  
• In vivo measurements of mitochondrial function and cell death following hypoxic/ischaemic damage to the new-born brain CE Cooper
  
• Mitochondria in heart ischaemia and ageing RG Hansford et al.
  
• Mitochondrial dysfunction in sepsis M Singer and D Brealey
  
• The mitochondrial permeability transition pore M Crompton et al.
  
• The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury AP Halestrap
• Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death JJ Lemasters et al.
  
  

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