Books

Essays in Biochemistry Volume 39
Programmed Cell Death

Available Online

Edited by T Cotter

University College, Cork, Ireland

Essays in Biochemistry

This new title in the Essays in Biochemistry series will:

highlight the role of apoptosis in developmental processes, in particular the contribution made by work carried out in Caenorhabditis elegans
focus on how discoveries in this model organism helped us understand the role played by key genes in higher organisms
emphasize the usefulness of model organisms in deciphering complex biological processes
introduce the caspase enzyme cascade and its contribution to the execution phase of the apoptosis pathway
discuss the mechanism of action of these enzymes, the use of inhibitors and the types of assay used to measure activity, etc.
outline the role of the mitochondrion, focusing on the involvement of reactive oxygen species, cytochrome c and other molecules that act at this subcellular site

Contents will include:

• Historical perspective
  
• Apoptosis and development
  
• Caspases: the enzymes of death
  
• The role of the mitochondrion
  
• Death receptors
  
• Bcl-2 family of proteins
  
• Oncogenes as regulators of apoptosis
  
• Recognition and removal of dead cells
  
• Apoptosis and disease
  
• Therapeutic approaches to the modulation of apoptosis
  
• Future perspectives
  
  

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