Books

Essays in Biochemistry Volume 41
The Ubiquitin-Proteasome System

Available Online

Edited by J Mayer and R Layfield

Nottingham, UK

Essays in Biochemistry

The importance of the ubiquitin-proteasome system in cellular homoeostasis was emphasized by the award of the 2004 Nobel Prize in Chemistry to the discoverers of ubiquitin as a cofactor for intracellular non-lysosomal proteolysis. There is a voluminous literature showing that protein ubiquitylation and the degradation of ubiquitylated proteins by the 26 S proteasome controls almost every regulatory process in the cell. The contributors to this volume of Essays in Biochemistry focus on many different aspects of the role of the ubiquitin system in intracellular proteolysis, not only in cellular homoeostasis, but also in relation to disease. Ubiquitylation compliments and rivals protein phosphorylation/dephosphorylation in the regulation of cellular activities. Understanding the ubiquitin-proteasome system and related mechanisms will provide new therapeutic avenues in a variety of unrelated human diseases.

Contents:

• Orchestra for assembly and fate of polyubiquitin chains T Hoppe et al.
• E3 ubiquitin ligases H Ardley and P Robinson
  
• Proteasome B Dahlmannn
  
• Ubiquitin-binding proteins: similar, but different R Hartmann-Petersen et al.
  
• Ubiquitin and control of transcription Z Nawaz et al.
  
• Ubiquitin and endocytic protein sorting S Urbé
  
• The ubiquitin-proteasome system in ER quality control Yihong Ye
  
• Fluorescent reporters for the ubiquitin-proteasome system N Dantuma
  
• Transgenic manipulation of the ubiquitin-proteasome system D Gray
  
• Targeting of host-cell ubiquitin pathways by viruses J Shackelford and J Pagano
• The ubiquitin-proteasome system and neurodegenerative disorders
  R Layfield et al.
  
• The ubiquitin-proteasome system and skeletal muscle wasting D Attaix et al.
  
• The ubiquitin-proteasome system and cancer J Mayer et al.
  
• Proteasome inhibitors as therapeutics C Mitsiades et al
  

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