Books

Biochemical Society Symposia Volume 70
Proteases and the Regulation of Biological Processes

Available Online

Edited by Jeremy Saklatvala, Hideaki Nagase and Guy Salvesen

Imperial College London, UK and The Burnham Institute, San Diego, USA

Biochemical Society Symposia

Proteases and the Regulation of Biological Processes is a collection of articles written by speakers at the 70th Annual Symposium of the Biochemical Society held at Imperial College, London in December 2002. It aims to provide an overview of the most up-to-date research on the roles of proteolytic enzymes in biological systems.

Topics covered include:

• Extracellular and pericellular proteolysis
  
• Inflammation and tissue destruction
  
• Protease inhibitors and potential for therapy
  
• Intracellular proteolysis and apoptosis
  
• Proteolysis and cell migration
  

• Structural basis of matrix metalloproteinase function
  
• Papain-like lysosomal cysteine proteases and their inhibitors: drug discovery targets?
  
• Roles for asparagine endopeptidase in class II MHC-restricted antigen processing
  
• Substrate specificity and inducibility of TACE revisited: the Ala-Val preference and induced intrinsic activity
  
• Meprin proteolytic complexes at the cell surface and in extracellular spaces
  
• Roles of TIMPs in pericellular proteolysis: the specificity is in the detail
  
• Collagen-platelet interactions: recognition and signalling
  
• Control of the expression of inflammatory response genes
  
• Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity
  
• Proteolysis of the collagen fibril in osteoarthritis
  
• Cytokine synergy, collagenases and cartilage collagen breakdown
  
• Proteolytic 'defences' and the accumulation of oxidized polypeptides in cataractogenesis and atherogenesis
  
• Proteases as drug targets
  
• How serpins change their shape for better and for worse
  
• Cystatins
  
• Designing TIMP variants that are selective metalloproteinase inhibitors
  
• Memapsin 2, a drug target for Alzheimer's disease
  
• Control of lipid metabolism by regulated intramembrane proteolysis of SREBPs
  
• Caspase activation
  
• Separase regulation during mitosis
  
• Membrane-type 1 matrix metalloproteinase and cell migration
  
• Cathepsin B and its role(s) in cancer progression
  
• Proteolytic and non-proteolytic migration of tumour cells and leucocytes
  
  

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