Books

Fundamentals of Enzyme Kinetics (3rd Edition)

By A Cornish Bowden

CNRS, Marseilles, France

General

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The new edition of Fundamentals of Enzyme Kinetics conserves the features that led reviewers of the second edition, published in 1995, to describe it as “truly excellent” (Protein Science), “the best presentation available” (Molecular Membrane Biology) and “outstanding and up to date” (Biochemical Education): there is no pretence of an encyclopaedic approach, but instead the emphasis is on the principles of enzyme kinetics, and especially on explaining these principles as simply and accurately as possible, so that readers will be well equipped to take the subject as far as they need.

All of the text has been thoroughly revised to explain concepts even more clearly, some of the material is reorganized into a more logical sequence, and there are many additions throughout the book. In particular, the important topic of irreversible inhibition is now covered in more detail than it was in previous editions, and there is a fuller discussion of methods for studying fast reactions. A novel feature is the inclusion of brief biographical sketches of ten of the scientists who developed our understanding and knowledge of enzyme catalysis. There are numerous new bibliographical references to take account of developments over recent years.

Contents:

• Basic Principles of Chemical Kinetics
  
• Introduction to Enzyme Kinetics
  
• Practical Aspects of Kinetic Studies
  
• Deriving Steady-State Rate Equations
  
• Reversible Inhibition and Activation
  
• Tight-binding and Irreversible Inhibitors
  
• Reactions of More than One Substrate
  
• Use of Isotopes for Studying Enzyme Mechanisms
  
• Effect of pH on Enzyme Activity
  
• Temperature Effects on Enzyme Activity
  
• Control of Enzyme Activity
  
• Kinetics of Multi-Enzyme Systems
  
• Fast Reactions
  
• Estimation of Kinetic Constants
  

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