Books

Biochemical Society Symposia Volume 71
Free Radicals: Enzymology, Signalling and Disease

Available Online

Edited by Chris Cooper (Essex, UK) Mike Wilson (Essex, UK) and Victor Darley-Usmar (Birmingham, AL, USA)

Biochemical Society Symposia

Free Radicals: Enzymology, Signalling and Disease is the published proceedings of the Biochemical Society's Annual Symposium held at the University of Essex in July 2003. The book aims to provide an overview of current research in free radical biochemistry from a variety of perspectives.

Topics covered include the role of radicals in enzymology, novel radical-mediated chemistry and new tricks to traditional 'radical enzymes', the role of radicals in signalling pathways, new targets for the nitric oxide pathway, signalling by oxygen radicals, and the toxicity of oxygen-based free radicals, nitrogen-based free radicals and the interaction between the two.

Contents Include:

• Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: the trimethylamine dehydrogenase electron transferring flavoprotein complex D. Leys et al.
  
• Cofactor processing in galactose oxidase S. Firbank et al.
  
• Defining substrate specificity and catalytic mechanism in ascorbate peroxidase E. Raven et al.
  
• Radical reactions of nitric oxide synthases D. Steuhr et al.
  
• Guanylyl cyclase: NO hits its target M. Russwurm et al.
  
• Nitric oxide signalling: insect brains and photocytes B. Trimmer et al.
  
• The use of model systems to study biological functions of Nox/Duox enzymes D. Ritsick et al.
  
• Activation of cytochrome c to a peroxidase compound I type intermediate by H₂O₂: relevance to redox signalling in apoptosis M. Burkitt et al.
  
• Redox signalling: from Nitric Oxide to oxidized lipids S. Shiva et al.
  
• Clinical aspects of reactive oxygen and nitrogen species A. Warnholtz et al.
  
• Regulation of vascular function by haemoglobin J. Crawford et al.
  
• Modulation of the L arginine nitric oxide signalling pathway in vascular endothelial cells A. Wyatt et al.
  
• Antioxidant and cytoprotective responses to oxidative stress J. Mathers et al.
  
• Generation of bile pigments by haem oxygenase: a refined cellular strategy in response to stressful insults R. Foresti et al.
  
• Metallic prions D. Brown
  
• Mitochondrial superoxide and aging: uncoupling protein activity and superoxide production M. Brand et al.
  
  

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