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Biochemical Society Symposia Volume 73
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Edited by S Roberts, R Weinzierl and R White

Biochemical Society Symposia

Gene transcription has remained at the forefront of modern biomedical science due to genome-sequencing projects, the renewed interest in the role of chromatin, the availability of high-resolution structures of key parts of the transcriptional machineries and new insights into the physiological role of transcription. This collection of reviews, based on presentations at the Biochemical Society's 2005 Annual Symposium, provides an overview of the current state of research into gene expression-mechanisms.

Contents:

• Investigations of the modular structure of bacterial promoters N Miroslavova and S Busby
  
• How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation D Higgs et al.
  
• MOZ fusion proteins in acute myeloid leukimia D Heery et al.
  
• Mechanistic studies of the mRNA transcription cycle P Cramer
  
• Modulation of RNA polymerase core functions by basal transcription factor TFB/TFIIB R Weinzierl et al.
  
• The relationship between higher order chromatin structure and transcription N Gilbert and W Bickmore
  
• Specialized transcription factories P Cook et al.
  
• A role for upstream binding factor in organising ribosomal gene chromatin B McStay et al.
  
• Nutrient regulated gene expression in eukaryotes R Reece et al.
  
• Chromatin remodelling factors and the maintenance of transcriptional states through DNA replication S Aligianni and P Varga Weisz
  
• Nucleosome dynamics T Owen Hughes et al.
  
• Convergence of the SUMO and MAP kinase pathways on the ETS-domain transcription factor Elk-1 S -H Yang and A Sharrocks
  
• Non coding RNA in transcription initiation A Akoulitchev et al.
  
• Activation by c Myc of transcription by RNA polymerases I, II and III R White et al.
  
• Both normal and polyglutamine expanded Ataxin 7 are components of TFTC type GCN5 histone acetyltransferase containing complexes L Tora et al.
  
• Regulation of NF kB function K Campbell and N Perkins
  
• The p53 response during DNA damage: impact of transcriptional cofactors A Coutts and N La Thongue
  
• The modulation of WT1 transcription function by cofactors S Roberts
  
• The RNA polymerase I transcription machinery J Russell and J Zomerdijk
  
• Fluorescence resonance energy transfer as a method for dissecting in vivo mechanisms of transcriptional activation M Green et al.
  
• Core promoter-selective RNA polymerase II transcription P Gross and T Oelgeschlager
  

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