Books

Essays in Biochemistry Volume 45
Systems Biology

Edited by Olaf Wolkenhauer, Peter Wellstead and Kwang-Hyun Cho

Essays in Biochemistry

The common ground for most perspectives of systems biology is the need to understand the dynamic function of cells as interacting objects, rather than focusing on static properties. This volume of Essays in Biochemistry is an attempt to pick and mix key topics in systems biology, allowing for different perspectives, while keeping a common goal: the understanding of the principles (mechanisms, laws) by which molecules and cells interact in order to realize their function.

Topics covered include modelling the dynamics of signalling pathways, modelling metabolic networks using power-laws and S-systems, modelling reaction kinetics in cells, the regulatory design of cellular processes, metabolomics and fluxomics, modelling cellular signalling systems, systems analysis of MAPK signal transduction, systems biology of JAK/STAT signalling, single live-cell imaging for systems biology, using thiamine uptake in yeast as a case study in systematic modelling, short-term volume and turgor regulation in yeast, network reconstruction based on steady-state data, sensitivity analysis, parameter estimation and optimal experimental design, standards and ontologies in computational systems biology, and systems biology model databases and resources.

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