Books

Essays in Biochemistry Volume 53
Cell Polarity and Cancer

Essays in Biochemistry

The majority of cells exhibit some form of polarization by having an asymmetric distribution of macromolecules within them. Epithelial cells, for example, have distinct apical and basolateral plasma membrane domains which are separated by specialized cell–cell junctions. This asymmetry is essential for cellular function. This volume of Essays in Biochemistry provides an overview of the regulation of cell polarity in epithelia, embryos and neurons, and how defects in cell polarity may contribute to tumorigenesis.

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